Christina Applegate was diagnosed with multiple sclerosis (MS) in 2021 and has since spoken about the debilitating disease. Here's everything to know about Christina Applegate's journey with multiple sclerosis (MS) and everything she's said about the disease.

In her new memoir, Applegate confirms that she ditched Pitt as her VMAs date for the Skid Row rocker in 1989.

The “Married … With Children” star was just 36 when a routine MRI in 2008 revealed early-stage breast cancer. Finding out she carried a BRCA1 mutation — a genetic trait that drastically increases cancer risk — Applegate made the gut-wrenching decision to undergo a double mastectomy and was later declared cancer-free.

Christina Applegate and Dutch bassist Martyn LeNoble wed in 2013, two years after welcoming their daughter

Her decision is sure to make you frown.

Christina Applegate has opened up about the early signs of multiple sclerosis that she initially ignored. The 54-year-old actress spoke to Robin Roberts on “Good Morning America” alongside her friend,

Brad Pitt was salty for years over Christina Applegate dumping him for Sebastian Bach. Bach spoke about the VMA pick up with a sense of pride.

Beginning at age 15, Applegate writes that she was "madly in love" with Depp, and the Married... With Children actress soon became a member of his friend group after guest starring on Depp's cop series, 21 Jump Street, often visiting him on set in Vancouver.