The West Virginia Mountaineers (2-6, 0-5 Big 12) and No. 22 Houston Cougars (7-1, 4-1) meet Saturday at TDECU Stadium in Houston, Texas. Kickoff is scheduled for noon ET (FS1). Let's analyze BetMGM Sportsbook's NCAA football odds around the West Virginia vs. Houston odds and make our expert college football picks and predictions for the best bets.

A fumble, two interceptions, and a muffed punt proved to be the difference maker for the Houston Cougars against the West Virginia Mountaineers.

The West Virginia Mountaineers face the No. 22 Houston Cougars on Saturday, Nov. 1, 2025 at TDECU Stadium in Houston, Texas.

The No. 22 Houston Cougars play host to the West Virginia Mountaineers this morning in a Week 10 battle between Big 12 Conference foes.

This article was originally published on www.si.com/college/westvirginia as Stock Up, Stock Down: Huge Progress Made in West Virginia's First Big 12 Win of 2025.