Cancer research, drug safety testing and aging biology may all gain a major boost from a new fluorescent sensor developed at Utrecht University. This new tool allows scientists to watch DNA damage and ...

Similar to the way DNA damage can contribute to human diseases such as cancer, it can also disrupt growth, development and survival in plants. Every day, plants endure environmental stresses such as ...

Newborn nerve cells must squeeze through crowded, narrow spaces-through dense tissue, past other cells, between fibers-to reach the areas where they form neural circuits in the brain cortex. In a new ...

In a quiet lab at Utrecht University, researchers have built a tool that lets you watch one of life’s most serious crises unfold in real time. Inside every cell, DNA breaks, repairs, and sometimes ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines are less effective. New research carried out by Dr. Loren Kell at NDORMS ...

The cancer drugs called PARP inhibitors have a puzzling reputation: even though they are treatment mainstays for multiple forms of cancer, they can damage cancer-killing T cells and disrupt the ...

Glioblastoma multiforme is characterised by rampant genomic instability and resistance to conventional chemoradiation, driven in part by a hyperactive DNA damage response (DDR). In normal cells, ...

The DNA damage response (DDR) constitutes a multifaceted network of sensors, transducers and effectors that preserves genome integrity by detecting and repairing lesions arising from endogenous ...

Cancer treatments like radiation and chemotherapy work by doing one main thing: shredding the DNA of cancer cells so they can no longer multiply.

A drug that has passed phase 1 trials for spinal injuries in people repaired DNA breaks and reduced inflammation in mouse ...

How long would humans live if we cured aging? Not merely slowing it but preventing the gradual breakdown that causes muscles ...

Newborn mice neurons can snap both DNA strands to migrate, then repair the breaks within a day. The process may be a normal part of brain development.