Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

The eukaryotic cell cycle orchestrates the orderly duplication and segregation of genetic material through distinct phases—G₁ (growth and monitoring), S (DNA synthesis), G₂ (preparation for division) ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...

Eukaryotic chromosomes replicate from multiple discrete loci termed origins of replication. These sites are first recognised by the origin recognition complex (ORC), which, together with Cdc6 and Cdt1 ...

For decades, scientists believed a fertilized egg’s DNA began as a shapeless mass, only organizing itself once the embryo switched on its genes. But new research reveals that the genome is already ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

DNA is often called the blueprint of life, but what does that really mean? Elizabeth Worthey, Ph.D., associate professor, Department of Genetics in the Heersink School of Medicine, explains everything ...

This voice experience is generated by AI. Learn more. This voice experience is generated by AI. Learn more. DNA doesn’t just carry information in its sequence; fleeting alternative folds like i‑DNA ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...