During the early phases of oncogenic clonal expansion, precancerous cells experience replication stress that threatens both genomic integrity and viability. How replication stress tolerance (RST) ...

DNA replication is the fundamental process by which cells duplicate their genetic material before division. Initiation occurs at defined origins where a hexameric helicase unwinds the double helix, ...

Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth—a key process in the origin of life. Scientists ...

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Cedars-Sinai scientists have created a new experimental drug called TY1 that helps the body repair damaged DNA and restore injured tissue. The discovery came from studying tiny molecular messages ...

A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA double ...

As antibiotic-resistant infections rise and are projected to cause up to 10 million deaths per year by 2050, scientists are looking to bacteriophages, viruses that infect bacteria, as an alternative.

CRISPR’s rise from obscure bacterial defense system to molecular scalpel has always hinged on one small component: the guide RNA. For years, that guide RNA—meticulously designed, modified, and ...

New method uses DNA barcodes for high throughput RNA and protein detection in deep tissue. ScienceDaily. Retrieved October 22, 2026 from www.sciencedaily.com / releases / 2025 / 03 / 250311121315.htm ...