Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - ...

Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...

A new study has revealed the mechanism of multimerization — the association of different molecules to form complex structures ...

The probability of drug interactions increases when genetic polymorphisms are considered, indicating that pharmacogenetic assessment may be useful in predicting the presence and severity of ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane ...

Glovadalen, a novel D1 receptor positive allosteric modulator, is linked to improve OFF time in patients with Parkinson’s ...

A recent Northwestern Medicine study has identified novel neural circuits modulated by the diabetes and obesity-management ...