Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal ...

As cells mature and differentiate (right), they use a much more elaborate and cell-type specific ‘switchboard’ to control their gene expression, especially when compared to earlier, immature stages ...

The human genome contains about 23,000 genes, but only a fraction of those genes are turned on inside a cell at any given time. The complex network of regulatory elements that controls gene expression ...

New study by Chiba University, Japan in collaboration with Karolinska Institutet, Sweden, uncovers novel enhancer-promoter interactions that regulate gene expression during neuronal differentiation ...