Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more ...

Humans have about 400 odorant receptors (ORs), but scientists have had trouble finding ligands that match up with most of ...

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - ...

A new study has revealed the mechanism of multimerization — the association of different molecules to form complex structures ...

The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

Presented at ASCO 2021 by Dr. de Bono, gumelutamide (TAS3681) is a third generation androgen receptor antagonist targeting the ligand binding domain, but this agent also had minimal activity based on ...

(1) Synthesis of Notch receptor in endoplasmic reticulum. (2) Notch receptor undergoing S1 cleavage by furine-like convertase in the Golgi apparatus. (3) The transfer of Notch receptor to the cell ...

The 2025 ESMO annual meeting featured a metastatic castration-resistant prostate cancer (mCRPC) session and a presentation by ...