A collaborative effort between Mount Sinai and Memorial Sloan Kettering Cancer Center has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help ...

Despite the replacement of the monoamine hypothesis of depression with a more comprehensive understanding of multiple influencing factors in the pathology of depression, it is clear that elevating ...

Neurotransmitters are chemical messengers that help nerve cells (neurons) communicate with one another. These chemical messengers affect the brain by either exciting (stimulating), inhibiting ...

Scientists have determined structures of a transporter protein involved in the movement of neurochemicals such as serotonin and dopamine, unearthing multiple mechanisms that can guide drug development ...

Researchers have known for decades that the brain has a remarkable ability to "reprogram" itself to compensate for problems such as traumatic injury. Now, a research ...

Scientists at St. Jude Children’s Research Hospital have drawn on structural biology expertise to determine structures of vesicular monoamine transporter 2 (VMAT2), a key component of neuronal ...

Also referred to as chemical messengers, neurotransmitters are chemical agents made and released by neurons. They are stored in vesicles at the terminal end (presynaptic terminal) of a neuron. Their ...

Geoffrey Attardo first tried Prozac to treat his depression when he was doing postdoctoral research at Yale School of Public Health and was feeling the pressures of a new job in academia. Soon after ...

Aromatic amino acid decarboxylase (AADC) deficiency is a rare, autosomal recessively inherited neurometabolic disorder characterised by markedly reduced synthesis of key monoamine neurotransmitters ...

Tissue-like probes: A three-channel NeuroString for brain implantation (left) and a micro-CT image showing a gut NeuroString placed in the mouse colon (right). (Courtesy: Jinxing Li, Zhenan Bao, ...

The number of people with depression has reached new highs—and so has antidepressant use. As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight U.S.