Cancer treatments like radiation and chemotherapy work by doing one main thing: shredding the DNA of cancer cells so they can no longer multiply.

DNA polymerases are central to the faithful duplication and maintenance of the genome. Beyond replication, specialised polymerases are recruited to distinct repair pathways to restore integrity after ...

Three biochemical steps of the non-homologous DNA end-joining (NHEJ) process. This figure outlines the key stages of the NHEJ repair mechanism following DNA double-strand breaks. The process can be ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

I. Platinum-based therapies induce DNA inter-strand crosslinks (ICLs), which exacerbate genomic instability and impede DNA replication. In BRCA1/2-deficient tumor cells, the repair of these DNA ...