The discovery of insulin has saved the lives of millions of people with diabetes worldwide, but little is known about the first step of insulin synthesis. The discovery of insulin has saved the lives ...

Type 2 diabetes arises from a combination of impaired insulin action and defective pancreatic β-cell function. Classically, the two abnormalities have been viewed as distinct yet mutually detrimental ...

Researchers design a novel algorithm for controlling implanted insulin pumps that accounts for the unique characteristics of individual patients. Their model, tested using an FDA-approved diabetes ...

While circulating levels of GLP-1 are decreased in type 2 diabetes, tissue response to the hormone remains intact. Evidence suggests that an impaired incretin effect is a result of clinical disease ...

Excessive sugar and fat in the diet can lead to hepatic (liver) insulin resistance. Often seen in people who are obese, hepatic insulin resistance leads to unhealthy levels of fatty lipids in the ...

Insulin is a glucose-lowering hormone that targets the peripheral tissues, especially the skeletal muscle and fatty tissues. Insulin also circulates throughout the brain, wherein it can impact the ...

Reviewed by Loren Wissner Greene, MD, MA (Bioethics), Clinical Associate Professor of Medicine, NYU School of Medicine, New York, NY For many years, it has been well known that causes of type 2 ...