Macromolecular crowding is a central concept in understanding how proteins function in the dense and heterogeneous intracellular environment. In crowded cellular conditions, high concentrations of ...

One of the hallmarks of Alzheimer's disease is the clumping of proteins called Tau, which form tangled fibrils in the brain.

High-pressure nuclear magnetic resonance (NMR) spectroscopy has emerged as a critical technique for investigating the structural dynamics of proteins under extreme conditions. By subjecting biological ...

Researchers at the University of Chicago and Argonne National Laboratory have been working on this problem for years; now, together with partners from Harvard University, they have perfected a new ...

An integrative modeling workflow to understand with atomistic precision biomolecular dynamics from high-speed atomic force microscopy experiments. (Nanowerk News) High-speed atomic force microscopy ...

Predicting protein structures from the amino acid sequences helps scientists to understand how proteins interact with other molecules, which is crucial for developing new drugs and therapies.

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...

A research team has developed a next-generation anti-inflammatory protein using AI and supercomputing. Subscribe to our newsletter for the latest sci-tech news updates. The team, led by Professor ...

Figure 1. This figure depicts the four categories of protein druggability target screening tools discussed in this section, which include structure-based methods, sequence-based methods, machine ...