When TDP-43 escapes from the nucleus, cells bungle mRNA processing, chopping up and splicing transcripts in the wrong places. Most studies have focused on retention of “cryptic” exons, but recent work ...
In amyotrophic lateral sclerosis and many cases of frontotemporal dementia, the RNA-binding protein TDP-43 abandons the nucleus and clumps up in cytoplasm, disrupting the normal workings of neurons ...
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