When the COVID-19 pandemic swept across the world in 2020, the mRNA vaccines came to the rescue of many people—but in the background there was another, lesser known, hero: the lipid nanoparticle.

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...

Lipid particles have been used in pharmaceutical developments for many years. LNPs are colloidal carriers that are submicron in size and have been developed to encapsulate pharmaceuticals while ...

Lipid nanoparticles have become the workhorse of mRNA vaccines, ferrying genetic cargo into cells so the immune system can learn to recognize a threat. But most LNPs don’t travel where vaccine ...

Lipid nanoparticles (LNPs) are the delivery vehicles of modern medicine, carrying cancer drugs, gene therapies and vaccines into cells. Until recently, many scientists assumed that all LNPs followed ...

Interest in lipid nanoparticles (LNPs) as delivery vehicles for precision therapies in genetic diseases and cancers remains at an all-time high. Now, scientists from the University of Pennsylvania, ...

Despite decades of study, a pharmacopoeia of medicines, and untold millions in pharmaceutical research, heart disease remains the leading cause of death around the world. Excess cholesterol in ...

Obesity and abnormal cholesterol levels are closely linked metabolic conditions that significantly increase the risk of heart ...