USB devices are block devices like any other. Linux doesn't care if you install or boot from a SATA disk or a USB disk, it makes no differences in that regard. The only niggle is can be BIOS support, ...

I connected a USB hub with power delivery to my Pomera (Debian), but for some reason, the battery kept draining... I've ...

It is an unfortunate fact of life that non-free firmware blobs are required to use some hardware, such as network devices (WiFi in particular), audio peripherals, and ...