Andrew G. Lee, MD, revisits a 1997 case in which recognizing paraneoplastic optic neuropathy led to the diagnosis—and life-saving treatment—of small cell lung carcinoma.

In a small study, 80% of testicular cancer patients developed paraneoplastic neurologic syndromes before their cancer diagnosis — highlighting a need for early detection.

Finger clubbing, a change in nail shape and fingertip swelling, can be an early indicator of lung cancer, though it often ...

The incidence of cancer is three times higher in patients with systemic sclerosis compared with the general population, ...

Neuroscientist Gerald Voelbel’s journey from mysterious symptoms to a rare cancer and neurological disorder diagnosis highlights the power of self-advocacy and finding purpose.

The paraneoplastic leukemoid reaction is a rare haematological paraneoplastic syndrome, which is typically seen with solid tumours and squamous cell carcinomas. As an indication of bone marrow ...

Stiff person syndrome (SPS) is a rare, debilitating neurological illness characterised by rigidity and spasms of the axial muscles, causing severe restrictions to mobility. SPS can be classic, partial ...

Lung cancer that spreads to the liver or pancreas can cause the skin to turn yellow. Tumors near the skin surface may appear as firm, round, painless lumps. Skin symptoms can be an unexpected sign of ...

1 Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan 2 Department of Clinical Pathology, Aomori Prefectural Central Hospital 3 Department of Neuropathology, Institute of Brain ...

Lung cancer recurrence is when cancer comes back after at least a year of being undetectable. Lung cancer often recurs within five years and is usually metastatic, meaning it has spread. Treatments ...

Small case series or well-described case reports also document painful mononeuritis multiplex and ICI-related sensory neuronopathy with and without anti-Hu (paraneoplastic) antibodies.

An expert discusses how treatment decisions must balance short-term burden with long-term benefits while avoiding ...