Doctors are alerted by digital clubbing, a bulbous swelling of fingertips, a sign known since ancient times. This often ...

Andrew G. Lee, MD, revisits a 1997 case in which recognizing paraneoplastic optic neuropathy led to the diagnosis—and life-saving treatment—of small cell lung carcinoma.

Neuroscientist Gerald Voelbel’s journey from mysterious symptoms to a rare cancer and neurological disorder diagnosis highlights the power of self-advocacy and finding purpose.

In a small study, 80% of testicular cancer patients developed paraneoplastic neurologic syndromes before their cancer diagnosis — highlighting a need for early detection.

Background: Paraneoplastic neurological syndromes (PNS) are defined by the presence of cancer and exclusion of other known causes of the neurological symptoms, but this criterion does not separate ...

Susan Bard, MD, is a board-certified general and procedural dermatologist with the American Board of Dermatology and a Fellow of the American College of Mohs Surgery. Pemphigus is a rare autoimmune ...

ABSTRACT: Paraneoplastic neurological syndromes (PNS) are rare disorders caused by an immune response against neuronal antigens expressed by an underlying malignancy. Anti-Hu-associated paraneoplastic ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Paraneoplastic syndrome represents severe and ...

Paraneoplastic syndromes affect multiple organs and are a central cause of mortality in cancer patients. In this issue, Cong et al (2025) report an inflammatory gut-kidney axis mediating systemic ...

ABSTRACT: The skin is the most visible organ of the human body and the second largest, surpassed only by the endothelium. Its functions extend beyond aesthetics, as it is considered the primary ...

Syndrome of Inappropriate Anti-Diuretic Hormone secretion, or SIADH, is a known complication of small-cell lung cancer (SCLC). SIADH makes your body produce too much of a hormone that causes your ...