Thorax

Extreme value analysis has the potential to improve spirometry interpretation

Background Spirometry is a measure of lung function used to make clinical decisions regarding the diagnosis and management of ...
Thorax

Frailty, comorbidity and survival comparisons between populations eligible for screening according to risk factor versus risk score criteria: results from the Yorkshir…

Background Lung cancer screening is effective for people at higher risk of the disease, but there is no international ...
Thorax

Upstaging of screen-detected lung cancers during diagnostic assessment

A key outcome from lung cancer screening studies is the concept of ‘stage-shift’ seen in screen-detected cancers compared ...
Thorax

Airway microbiota in young people across four continents differ by country, asthma status and inflammatory phenotype

Background Asthma is an umbrella diagnosis encompassing distinct pathophysiological mechanisms. While a global problem, our ...
Thorax

Minimal important difference of quadriceps maximal voluntary contraction (QMVC) in COPD: a prospective cohort study

Background Quadriceps maximal voluntary contraction (QMVC) reliably measures quadriceps muscle force and predicts mortality in chronic obstructive pulmonary disease (COPD). However, the minimal ...
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Getting more than early detection from lung cancer screening

Lung cancer (LC) remains the deadliest cancer in the world and LC screening programmes continue to expand across healthcare systems to improve outcomes by earlier detection.1 Following results from ...
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Clinical impact of customised positive airway pressure (PAP) therapy interfaces (3DPiPPIn): a single site randomised controlled trial

Introduction Positive airway pressure (PAP) therapy is the recognised treatment for sleep disordered breathing (SDB), delivered via a tight-fitting face mask (interface). Conventional interfaces do ...
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The impact of benzodiazepines on occurrence of pneumonia and mortality from pneumonia: a nested case-control and survival analysis in a population-based cohort

2 Department of Leucocyte Biology and Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK 3 Wellcome Department of Imaging Neuroscience, University College London, ...
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Gender differences in COPD: are women more susceptible to smoking effects than men?

2 Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway 3 Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway 4 Channing Laboratory and Pulmonary and ...
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Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete

Background: Atopy is not uncommon among children living in rural Crete, but wheeze and rhinitis are rare. A study was undertaken to examine whether this discrepancy could be attributed to a high ...
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Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC)

Background: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence and severity of asthma symptoms in children. Methods: A cross-sectional ...
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Home-based rehabilitation for COPD using minimal resources: a randomised, controlled equivalence trial

4 The Nossal Institute for Global Health, The University of Melbourne, Melbourne, Victoria, Australia Background Pulmonary rehabilitation is a cornerstone of care for COPD but uptake of traditional ...