Glucagon-like peptide 1 receptor agonists (GLP-1RA) have made waves as treatments for obesity and type 2 diabetes, but a new report suggests they might also have clinical benefits for certain patients ...

The NFL schedule turns the calendar to October in Week 5. The NFL Week 5 odds begin with another NFC West war on Thursday night, this time between the San Francisco 49ers and Los Angeles Rams. We get ...

In two new studies, scientists at Oregon Health & Science University have uncovered detailed blueprints of how certain molecular "gates" in human cells work—findings that could open doors to new ...

Scientists at Leipzig University have identified a little-known receptor, GPR133, as a key player in bone health. By stimulating this receptor with a new compound called AP503, they were able to boost ...

Psoriasis and psoriatic arthritis (PsA) are chronic, immune-mediated inflammatory diseases associated with several shared common comorbidities, of which obesity is one of the most prevalent. A complex ...

Neurons activated by the psychedelic 5-MeO-DMT light up across an entire hemisphere of the mouse brain. In this 3D image, colors cycle with depth and the tissue has been spatially distorted to mimic ...

High-resolution 3D image showing how the 5-HT1A receptor connects with internal signaling proteins (G proteins). The highlighted areas reveal key contact points between the receptor and two different ...

In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights ...

Provided herein are novel substituted pyrazoles as 5-HT1A agonists, pharmaceutical compositions, use of such compounds in treating neuropsychiatric diseases, and processes for preparing such compounds ...