Matching gene expression to metabolite production in single plant cells

A research team at the Max Planck Institute for Chemical Ecology has successfully combined single-cell RNA sequencing ...
Business Wire

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological ...
Morningstar

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB) Breakthrough Therapy ...
Frontiers

Soil-specific enzyme activity provides novel insight into the soil microbial necromass accumulation during sand dune fixation

Introduction: Soil enzymes are critical to plant growth and soil carbon turnover. However, the traditional method of assessing enzyme activity per unit of soil may be insufficient; instead, ...
C&EN

Catalytic Residue Reprogramming Enhances Enzyme Activity at Alkaline pH via Phenolate-Mediated Proton Transfer

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Directed evolution offers a complementary strategy by ...
IEEE

Simultaneous Measurement of Enzyme Activity and Concentration via a Multiplexed Photonic Sensor

Abstract: Enzyme assays are a cornerstone of basic biology and clinical diagnostics. While enzymatic assays are frequently used to indicate disease,[1] changes in enzyme activity can occur due to ...
C&EN

Methods, Applications, and Challenges of Enzyme Immobilization on Nanomaterials

Chapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
SciTech Daily

“Astounding” Results: Blocking One Enzyme Brings Parkinson’s-Damaged Cells Back to Life

In a breakthrough study, scientists found that silencing a single overactive enzyme in the brain reversed early damage caused by a Parkinson’s-related mutation in mice. The treatment restored the ...
Science Daily

Parkinson’s reversal? One drug brings dying brain cells back to life

Stanford researchers discovered that dialing down an overactive enzyme, LRRK2, can regrow lost cellular “antennae” in key brain cells, restoring vital dopamine communication and neuroprotective ...
PNAS

A responsive living material prepared by diffusion reveals extracellular enzyme activity of cyanobacteria

Previously described engineered living materials (ELMs) have been created with nonresponsive, biocompatible polymers by adding living cells to a precursor solution before polymerization, which cells ...
Frontiers

Modification of aggregation-prone regions of Arabidopsis glutamyl-tRNA reductase leads to increased stability while maintaining enzyme activity

The aggregation-prone region (APR) is a hydrophobic polypeptide motif that promotes protein aggregation, most commonly in the unfolded or misfolded state. It has been described that chaperones can ...
GEN

AI-Driven Protein Design Produces Enzyme that Mimics Natural Hydrolase Activity

A new method that successfully designs serine hydrolase enzymes capable of catalyzing ester hydrolysis with high efficiency, demonstrates a computational approach for creating de novo enzymes that ...