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Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial)

2 Centre Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Northern Ireland, UK Objective To investigate the effectiveness of a 6-week exercise ...
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Bronchoscopic transparenchymal nodule access (BTPNA): first in human trial of a novel procedure for sampling solitary pulmonary nodules

Introduction The promise of benefits from lung cancer screening is tempered by the false positive rate and the need to perform diagnostic procedures to determine the aetiology of the solitary ...
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Combining clinical, radiological and genetic approaches to pneumothorax management

Familial spontaneous pneumothorax (FSP) accounts for 10% of primary spontaneous pneumothoraces. Appropriate investigation of FSP enables early diagnosis of serious monogenic diseases and the practice ...
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NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFβ1-induced fibroblast differentiation into ...

Background Persistence of myofibroblasts is believed to contribute to the development of fibrosis in idiopathic pulmonary fibrosis (IPF). Transforming growth factor β1 (TGFβ1) irreversibly converts ...
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Lung cancer, genetic predisposition and smoking: the Nordic Twin Study of Cancer

Background We aimed to disentangle genetic and environmental causes in lung cancer while considering smoking status. Methods Four Nordic twin cohorts (43 512 monozygotic (MZ) and 71 895 same sex ...
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Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort

Background Conflicting evidence has emerged regarding the relevance of smoking on risk of COVID-19 and its severity. Methods We undertook large-scale observational and Mendelian randomisation (MR) ...
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Community-acquired pneumonia as medical emergency: predictors of early deterioration

9 Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL) Background Early organ dysfunction determines the prognosis of ...
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A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD

2 University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands Correspondence to Dr Corry-Anke Brandsma, Department of ...
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Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial

Purpose To investigate the effect of functional electrical stimulation-assisted cycle ergometry (FES-cycling) on muscle strength, cognitive impairment and related outcomes. Methods Mechanically ...
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Effects of exercise training in people with non-small cell lung cancer before lung resection: a systematic review and meta-analysis

Introduction Exercise training before lung resection for non-small cell lung cancer is believed to decrease postoperative complications (POC) by improving cardiorespiratory fitness. However, this ...
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Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?

1 School of Nursing and Midwifery, University of Newcastle, Newcastle, New South Wales, Australia 2 School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia ...
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Lower airway microbiota in COPD and healthy controls

Background The lower airway microbiota in patients with chronic obstructive pulmonary disease (COPD) are likely altered compared with the microbiota in healthy individuals. Information on how the ...