AHA/ASA Journals17h
Withdrawal of Guideline-Directed Medical Therapy in Patients With Heart Failure and Improved Ejection Fraction
BACKGROUND: Limited evidence exists on the prognostic role of continuing medical therapy in patients with heart failure (HF) ...
AHA/ASA Journals4d
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...
ahajournals.org5d
Direct-to-Consumer Genetic Testing for Cardiovascular Disease: A Scientific Statement From the American Heart Association
Despite insufficient evidence to support direct-to-consumer genetic testing in routine clinical care, cardiovascular clinicians increasingly face questions about its utility and interpretation because ...
AHA/ASA Journals5d
Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk
High genetic susceptibility to type 2 diabetes is associated with higher atherosclerotic cardiovascular disease risk and ≤1 h/d of television viewing has substantially lower risk of atherosclerotic ...
ahajournals.org6d
PCSK9 Promotes LDLR Degradation by Preventing SNX17-Mediated LDLR Recycling
Low-density lipoprotein (LDL) is internalized into cells mainly through LDLR (LDL receptor)–mediated endocytosis. In an acidic endosome, LDLR is released from LDL and recycles back to the cell surface ...
ahajournals.org6d
Sex Differences in Peripheral Vascular Disease: A Scientific Statement From the American Heart Association
Sex differences in the risk factors, diagnosis, treatment, and outcomes of patients with cardiovascular disease have been well described; however, the bulk of the literature has focused on heart ...