In a cross-sectional study, the researchers reported psychiatric comorbidities in 46.5% of 43,270 adults with neurofibromatosis. The most common psychiatric comorbidities included mood disorders (22.1 ...

Wild-type ATTR-CM comprised 76% of cardiac amyloidosis cases, with prevalence highest in Asia and lowest in North America. Cardiac amyloidosis (CA) is present in approximately 10% of patients with ...

The Reagan-Udall foundation was named for President Ronald Reagan and Congressman Morris “Mo” Udall from Arizona, each of whom had an incurable neurodegenerative disease. The Reagan-Udall Foundation ...

Normalization of C1 inhibitor activity and C4 levels supported reclassification to type 3 disease after years of presumed type 2 angioedema. Reclassification of hereditary angioedema (HAE) subtype ...

The estimated 2022 incidence of overall ATTR amyloidosis, transthyretin-mediated amyloid cardiomyopathy (ATTR-CM), and transthyretin amyloid polyneuropathy (ATTR-PN) were 16.6, 12.7, and 3.5 cases per ...

Spesolimab is a humanized monoclonal immunoglobulin G1 antibody and is the first therapy to target the IL-36 pathway, a key driver of GPP disease processes. Spesolimab has an acceptable safety profile ...

If approved, CAM2029 could offer a self-administered alternative to intramuscular long-acting somatostatin analogs, with the potential to reduce treatment burden. The US Food and Drug Administration ...

Fenebrutinib demonstrated noninferiority to ocrelizumab in patients with PPMS, a population with limited treatment options. Genentech has reported that fenebrutinib reduced relapse rates in relapsing ...

Most attacks achieving symptom relief within 12 hours (96% of laryngeal and 95.8% of abdominal) did so with a single dose of sebetralstat. Oral sebetralstat is a rapid, well-tolerated, and effective ...

The guidelines highlight the unique needs of females and children, reflecting differences in disease presentation, triggers, and management. The Polish Society of Allergology has released updated 2025 ...

Statin treatment reduces the expression of TOMM40 and TOMM22, thereby impairing mitochondrial function. Statins effectively lower plasma low-density lipoprotein cholesterol levels, but they also ...

The recommendations were based on the available evidence, its certainty, and key judgments using the Grading of Recommendations Assessment, Development and Evaluation framework. New guidelines ...