p53 - Wikipedia
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …
Tumor Suppressor p53: Biology, Signaling Pathways, and …
This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response …
The TP53 Gene and Its Role in Cancer - Verywell Health
Dec 19, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations in the …
Targeting p53 pathways: mechanisms, structures and advances in …
Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …
The Multifaceted Role of p53 in Cancer Molecular Biology ... - MDPI
Jul 27, 2025 · Exploring the diverse roles of p53, which include regulating the cell cycle, repairing DNA, inducing apoptosis, reprogramming metabolism, and modulating immunity, provides …
What Is the P53 Gene and How Does It Prevent Cancer?
The p53 gene, officially known as TP53, is a critical tumor suppressor in human biology. This gene encodes the p53 protein, which acts as the cell’s primary safeguard against the …
Recent findings on the role of wild-type and mutant p53 in cancer ...
Sep 26, 2022 · The p53 protein is a tumor suppressor encoded by the TP53 gene and consists of 393 amino acids with four main functional domains. This protein responds to various cellular …
p53 Function and Dysfunction in Human Health and Diseases
The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and …
Researchers Uncover How Tumors Become Resistant to Promising p53 …
4 days ago · This druggable cavity has led to the development of small molecules such as rezatapopt that are designed to restore p53 and reactivate its normal tumor suppressor …
p53-regulated non-apoptotic cell death pathways and their
Apr 9, 2025 · This Review discusses the roles, mechanisms and physiological settings in which NACDs are regulated by p53, and their potential targeting for the treatment of human diseases.