Using cryo-electron microscopy, researchers - including HHMI Investigators Eva Nogales and Russell Vance - have revealed the structure of a multi-protein complex called the NAIP5-NLRC4 inflammasome, which helps identify invading bacteria. Read more: http://bit.ly/2ilHUID | Howard Hughes Medical Institute
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🔥 NLRP3 Inflammasome: The Heart’s 🫀 Inflammatory-Arrhythmic Link Beyond driving atherosclerosis and myocardial inflammation, NLRP3 activation directly impairs cardiomyocyte calcium handling via RyR2 dysfunction, creating a novel pathway linking systemic inflammation to life-threatening arrhythmias. Mechanism: Disrupted excitation–contraction coupling forms a direct molecular bridge between innate immunity and electrical instability. Source: Front Immunol. 2025 | DOI:10.3389/fimmu.2025.1550206
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